biomaterials
Fibrous materials with 8-hydroxyquinoline included in an amorphous state were obtained. The antimicrobial activity of the obtained fibrous materials against the pathogenic bacteria S. aureus and E. coli, as well as against the fungi C. albicans, P. chlamydospora and P. aleophilum was proven. The materials also exhibited high cytotoxicity against HeLa cervical cancer cells and against SH-4 melanoma cells.
biomaterials
The development concerns a colloidal aqueous system based on silymarin in liquid and gel form, obtained using an amphiphilic polyether block copolymer approved for use in food and medicine. The liquid formulation can be administered parenterally, orally, in the form of a spray and drops. The gel can be applied dermally. The improved solubility in water, combined with the beneficial properties of silymarin, makes the colloidal system based on silymarin, in any of its forms, suitable for use in the pharmaceutical, food industry, human and veterinary medicine and cosmetics. The results are reflected in a registered utility model: Petrov P., Mehandzhieva V., Ivanov V. Colloidal water system based on silymarin, BG 4347/06.10.2022.
Contact:
ppetrov@polymer.bas.bg
biomaterials
Ccopolymers were obtained as potential nanocarriers of hydrophobic biologically active substances, which self-associate in an aqueous medium, forming micelles of the “core-shell” type. The obtained copolymer was further modified with side amino groups to a hydrophilic block copolymer with the potential application in nanomedicine as carriers of low molecular weight active substances and DNA.
Contact:
office@jic.bas.bg
