{"id":2438,"date":"2022-12-28T11:26:25","date_gmt":"2022-12-28T11:26:25","guid":{"rendered":"https:\/\/jic.bas.bg\/tehnologii\/biotehnologii\/"},"modified":"2024-10-11T15:14:18","modified_gmt":"2024-10-11T15:14:18","slug":"biotehnologies","status":"publish","type":"page","link":"https:\/\/jic.bas.bg\/en\/tehnologies\/biotehnologies\/","title":{"rendered":"Biotechnologies"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2438\" class=\"elementor elementor-2438 elementor-128\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eef0fd2 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"eef0fd2\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a95e6e6\" data-id=\"a95e6e6\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8227f7 elementor-widget elementor-widget-image\" data-id=\"f8227f7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"437\" height=\"289\" src=\"https:\/\/jic.bas.bg\/wp-content\/uploads\/2023\/03\/Bio-tehnologii-Jic-bas-bg.png\" class=\"attachment-full size-full wp-image-2152\" alt=\"\" srcset=\"https:\/\/jic.bas.bg\/wp-content\/uploads\/2023\/03\/Bio-tehnologii-Jic-bas-bg.png 437w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2023\/03\/Bio-tehnologii-Jic-bas-bg-300x198.png 300w\" sizes=\"(max-width: 437px) 100vw, 437px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-fe6a415\" data-id=\"fe6a415\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58204cb elementor-widget elementor-widget-heading\" data-id=\"58204cb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">BIOTECHNOLOGIES<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a5cea7 elementor-widget elementor-widget-text-editor\" data-id=\"9a5cea7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A microbial community with an unknown polycaprolactone (PCL) degradation efficiency was isolated from a hot spring in Marikostinovo, Bulgaria. The optimum temperature for the degradation process of 55\u00b0C is the highest known so far for PCL degradation.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7233e2d elementor-widget elementor-widget-text-editor\" data-id=\"7233e2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Changes after 3-week cultivation of Brevibacillus thermoruber strain 7 isolated from the bacterial community.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9d1aa8b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9d1aa8b\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-98871f3\" data-id=\"98871f3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fbfd7df elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"fbfd7df\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/microbio.bas.bg\/en\/%20\" target=\"_blank\" rel=\"nofollow\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Institute of Microbiology - BAS<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cfbe142 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cfbe142\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ee709e6\" data-id=\"ee709e6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b51ff52 elementor-view-stacked elementor-shape-square elementor-widget elementor-widget-icon\" data-id=\"b51ff52\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-envelope\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2faff3 elementor-widget elementor-widget-heading\" data-id=\"c2faff3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Contact<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-523ece4 elementor-icon-list--layout-inline elementor-align-center elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"523ece4\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"mailto:margikam@microbio.bas.bg\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">margikam@microbio.bas.bg<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-541a8fb elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"541a8fb\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-07f8c6c\" data-id=\"07f8c6c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-393e58d elementor-widget elementor-widget-image\" data-id=\"393e58d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2457\" height=\"418\" src=\"https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/Ru-catalyzed-allylic-isomerization-IOCCP.jpg\" class=\"attachment-full size-full wp-image-6046\" alt=\"\" srcset=\"https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/Ru-catalyzed-allylic-isomerization-IOCCP.jpg 2457w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/Ru-catalyzed-allylic-isomerization-IOCCP-300x51.jpg 300w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/Ru-catalyzed-allylic-isomerization-IOCCP-1024x174.jpg 1024w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/Ru-catalyzed-allylic-isomerization-IOCCP-768x131.jpg 768w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/Ru-catalyzed-allylic-isomerization-IOCCP-1536x261.jpg 1536w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/Ru-catalyzed-allylic-isomerization-IOCCP-2048x348.jpg 2048w\" sizes=\"(max-width: 2457px) 100vw, 2457px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-09bdbc6\" data-id=\"09bdbc6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3125f00 elementor-widget elementor-widget-heading\" data-id=\"3125f00\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">BIOTECHNOLOGIES<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-617714b elementor-widget elementor-widget-text-editor\" data-id=\"617714b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A highly efficient Ru-catalyzed allylic isomerization of renewable Akhmatovich products is reported for the first time. The method developed at the IOCCP-BAS is of importance for biorefinery and green chemistry, as it uses a formally redox-neutral process to obtain biorenewable monomers and biologically active compounds. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-85e6417 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"85e6417\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-bd82c0c\" data-id=\"bd82c0c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c838a8 elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"7c838a8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.orgchm.bas.bg\/EN\/index_en.html\" target=\"_blank\" rel=\"nofollow\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Institute of Organic Chemistry with Centre of Phytochemistry - BAS<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e4fc1c4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e4fc1c4\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ccea683\" data-id=\"ccea683\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b64b473 elementor-view-stacked elementor-shape-square elementor-widget elementor-widget-icon\" data-id=\"b64b473\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-envelope\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d61006 elementor-widget elementor-widget-heading\" data-id=\"4d61006\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Contact<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f3ddae elementor-icon-list--layout-inline elementor-align-center elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"8f3ddae\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"mailto:office@jic.bas.bg\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">office@jic.bas.bg<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-aeca16b elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"aeca16b\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8de9624\" data-id=\"8de9624\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-935cb16 elementor-widget elementor-widget-image\" data-id=\"935cb16\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"894\" height=\"503\" src=\"https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/biosensor-technology-detecting-pathogens-gases-pesticides-.jpg\" class=\"attachment-full size-full wp-image-6180\" alt=\"\" srcset=\"https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/biosensor-technology-detecting-pathogens-gases-pesticides-.jpg 894w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/biosensor-technology-detecting-pathogens-gases-pesticides--300x169.jpg 300w, https:\/\/jic.bas.bg\/wp-content\/uploads\/2024\/09\/biosensor-technology-detecting-pathogens-gases-pesticides--768x432.jpg 768w\" sizes=\"(max-width: 894px) 100vw, 894px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5fe6468\" data-id=\"5fe6468\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1114fdb elementor-widget elementor-widget-heading\" data-id=\"1114fdb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">BIOTECHNOLOGIES<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fef240 elementor-widget elementor-widget-text-editor\" data-id=\"4fef240\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Institute of Optical Materials and Technologies &#8220;Acad. Jordan Malinowski&#8221; presents <b>biosensor technology for detecting pathogens\/gases\/pesticides<\/b>. <br \/>A method based on laser ablation has been technologically mastered to immobilize the recognition substance on the optical transducer. The method, called MAPLE, provides direct immobilization (without the presence of an embedding matrix of intermediary molecules) of the recognition molecules. The method has been tested for immobilization of haemoglobin, myoglobin, antibodies and antigens. Precise control of the thickness of the molecular layers while preserving their bioactivity has been achieved. The absence of an embedding matrix ensures the maximum possible specificity inherent only to the recognition molecules. This solves the specificity problem.       <br \/>Control of the MAPLE process parameters allow the creation of a nanostructured layer of the required thickness. This process largely determines the detection sensitivity. Proof of the effectiveness of the process is the reached sensitivity of 120 fM in the detection of SARS CoV-2 proteins.  <br \/>The element that converts changes in the bioactive layer caused by bimolecular reactions into an optical signal is a metallized diffraction grating. The approach of using a metallized diffraction grating disproves the widely held belief that this detection method has a sensitivity about an order of magnitude less than that of prism detection.  <br \/>The use of suitable diffraction gratings solves the problem of sensitivity and the difficulty of handling them with a sample under investigation.<br \/>The technology of immobilization of recognition molecules, as well as the technology of manufacturing diffraction gratings, have been fully mastered.<br \/>A prototype of the biosensor was created, including all optical and detection elements, representing a small, compact device. Functionality is proven in a simulated environment. The measuring equipment is laboratory instruments.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b335f3d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b335f3d\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-afbd0ca\" data-id=\"afbd0ca\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e12740 elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"1e12740\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/iomt.bas.bg\/home\/\" target=\"_blank\" rel=\"nofollow\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Institute of Optical Materials and Technologies \"Acad. Jordan Malinowski\"  <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e75589f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e75589f\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8be94af\" data-id=\"8be94af\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a2de359 elementor-view-stacked elementor-shape-square elementor-widget elementor-widget-icon\" data-id=\"a2de359\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-envelope\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2747a21 elementor-widget elementor-widget-heading\" data-id=\"2747a21\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Contact<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37d7396 elementor-icon-list--layout-inline elementor-align-center elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"37d7396\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"mailto:office@jic.bas.bg\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">office@jic.bas.bg<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>BIOTECHNOLOGIES A microbial community with an unknown polycaprolactone (PCL) degradation efficiency was isolated from a hot spring in Marikostinovo, Bulgaria. The optimum temperature for the degradation process of 55\u00b0C is the highest known so far for PCL degradation. Changes after 3-week cultivation of Brevibacillus thermoruber strain 7 isolated from the bacterial community. Institute of Microbiology [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2311,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2438","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/pages\/2438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/comments?post=2438"}],"version-history":[{"count":7,"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/pages\/2438\/revisions"}],"predecessor-version":[{"id":6447,"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/pages\/2438\/revisions\/6447"}],"up":[{"embeddable":true,"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/pages\/2311"}],"wp:attachment":[{"href":"https:\/\/jic.bas.bg\/en\/wp-json\/wp\/v2\/media?parent=2438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}